韩家淮实验室
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About PI

Jiahuai Han, Ph.D.

Professor, School of Life Sciences at Xiamen University
Distinguished Professor of Chinese “Thousand Talents Program”
Distinguished Professor of Chinese “Chang Jiang Scholars Program”
Elected Member, the National Academy of Sciences of China

Administrative positions:
Dean, Faculty of Medicine and Life Sciences, Xiamen University, China
Director, State Key Laboratory of Cellular Stress Biology
Director, Innovation Center for Cell Signaling Network
Director, Laboratory Animal Center, Xiamen University, China
Vice President, Xiamen University, Xiamen, China.
Vice President, Chinese Society for Cell Biology.

Education:
B.S., Beijing University (Peking University), China, 1982. Specialty in Biochemistry
M.S., Beijing University, China, 1985. Specialty in Protein Chemistry
Ph.D., University of Brussels (University Libre de Bruxelles), Belgium, 1990. Specialty in Molecular Biology

韩家淮
 

Research and Professional Experience:
1987 – 1992  Research Fellow, Department of Internal Medicine and Howard Hughes Medical  Institute, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
1992 – 1993  Research Associate, Department of Immunology, The Scripps Research Institute, La Jolla, California, USA
1993 – 1996  Assistant Member (Assistant Professor), Department of Immunology, The Scripps Research Institute, La Jolla, California, USA
1996 – 2004  Associate Professor, Department of Immunology, The Scripps Research Institute, La Jolla, California, USA
2004 – 2007  Professor, Department of Immunology, The Scripps Research Institute, La Jolla, California, USA
2007 – Present   Adjunct Professor (Professor of Immunology), Department of Immunology, The Scripps Research Institute, La Jolla, California, USA
2007 – Present  Professor, School of Life Sciences, Xiamen University, China

Awards:
Jean Stas Award (Belgium), 1991
Established Investigatorship Award (American Heart Association), 1995
Distinguished Young Scholar (B class, National Science Foundation of China), 2001
Chang Jiang Scholar (The Ministry of Education, China), 2002
Lu Jiaxi Excellent Mentor (Lu Jiaxi Science and Education Foundation), 2009
YaoMingKangDe Life Science and Chemistry Award (1st Prize, Wuxi Pharma), 2009
Chang Jiang Scholar Achievement Award (The Ministry of Education of China), 2009
First Prize in Natural Science Research (The Ministry of Education of China), 2011
Voted one of the ten most innovative scientists in China (Chinese Science Net), 2011
Overseas Chinese Contribution Award (All-China Fed. Returned Overseas Chinese), 2012
Nationwide Outstanding Doctoral Dissertation, Mentor Award (The Ministry of Education of China), 2012
The sixth Tan Jiazhen Life Science Achievement Award (Tan Jiazhen Award Foundation), 2013
The Second Prize of National Natural Science Award (The State Council, China), 2013
Outstanding scientific and technological expert in Fujian (Fujian province government, China), 2014
Outstanding scientific and technological expert in China (China Association for Science and Technology), 2014
Sanofi- Cell Research Outstanding Paper Prize, 2014

Professional Society Members for:
American Society for Molecular Biology and Biochemistry
The American Association of Immunologists
American Society for Microbiology
International Society of Endotoxin
International Communication Committee of Chinese Society for Genetics
Protein Committee of Chinese Society for Biochemistry and Molecular Biology (Vice Chairperson)
Chinese Society for Cell Biology (Vice President)

Patents:
1. Patent Number: 5,837,810
Date of Issue: 1998.11.17
Name of Patent: Polypeptides of lipopolysaccharide binding protein
2. Patent Number: 6,010,856
Date of Issue: 2000.01.04
Name of Patent: Assay systems and methods for measuring p38 MAP kinase, and modulators thereof
3. Patent Number: WO 2008/057171 A2
Date of Issue: 2007.10.16
Name of Patent: 4-1BB ligand in inflammatory diseases. Polypeptides of lipopolysaccharide binding protein
4. Patent Number: ZL 200810071442.X
Date of Issue: 2008.12.10
Name of Patent: 聚苯乙烯-聚(苯乙烯-交替甘露糖基马来酸)及其制备方法与应用
5. Patent Number: ZL 200810071898.6
Date of Issue: 2009.02.11
Name of Patent: 聚(苯乙烯-交替-马来酸钠)的用途
6. Patent Number: ZL 2007 1 0009304.4
Date of Issue: 2012.02.01
Name of Patent:高唾液酸含量的免疫球蛋白抗体的制备方法与应用

Study in Han’s laboratory:
Dr. Jiahuai Han is known for the discovery of the p38 signaling pathway, one of the most important pathways in intracellular signaling transduction. This pathway plays important roles in many biological processes including cell cycle regulation, cell proliferation, cell differentiation and senescence, as well as immune reactions, development and tumorigenesis. Another current focus of Han`s lab is molecular mechanisms of RIP3 dependent necrosis, which is based on a recent finding in this laboratory revealing that RIP3 is a major player in controlling programmed necrosis.
The research in Han’s Lab will lead to a better understanding of the molecular mechanisms of inflammation, cardiovascular disease and tumorigenesis, and thus provides new ideas for the development of therapeutic intervention for these diseases.