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Jiahuai Han:
Dr. Jiahuai Han is known for the discovery of the p38 signaling pathway, one of the most important pathways in intracellular signaling transduction. This pathway plays important roles in many biological processes including cell cycle regulation, cell proliferation, cell differentiation and senescence, as well as immune reactions, development and tumorigenesis. Another current focus of Han`s lab is molecular mechanisms of RIP3 dependent necrosis, which is based on a recent finding in this laboratory revealing that RIP3 is a major player in controlling programmed necrosis.

The research in Han’s Lab will lead to a better understanding of the molecular mechanisms of inflammation, cardiovascular disease and tumorigenesis, and thus provides new ideas for the development of therapeutic intervention for these diseases...(More)

Research:
Our research interests are the molecular mechanisms in stress responses including inflammation and inflammation related diseases.(More)

Selected Papers:
 1.    Zhang DW, Shao J, Lin J, Zhang N, Lu BJ, Lin SC, Dong MQ, Han J. RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science, 325 (5938):332-336, 2009.

 2.    Sun P, Yoshizuka N, New L, Moser BA, Li Y, Liao R, Xie C, Chen J, Deng Q, Yamout M, Dong MQ, Frangou CG, Yates JR, 3rd, Wright PE, Han J. PRAK is essential for ras-induced senescence and tumor suppression. Cell, 128 (2):295-308, 2007.

 3.    Jing Q, Huang S, Guth S, Zarubin T, Motoyama A, Chen J, Di Padova F, Lin SC, Gram H, Han J. Involvement of microRNA in AU-rich element-mediated mRNA instability. Cell, 120 (5):623-634, 2005.

 4.    Ge B, Gram H, Di Padova F, Huang B, New L, Ulevitch RJ, Luo Y, Han J. MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha. Science, 295 (5558):1291-1294, 2002.

 5.    Han J, Jiang Y, Li Z, Kravchenko VV, Ulevitch RJ. Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation. Nature, 386 (6622):296-299, 1997.

 6.    Han J, Lee JD, Bibbs L, Ulevitch RJ. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science, 265 (5173):808-811, 1994.(More)