课题介绍：

       生物体内存在着抵御外界感染与侵害，清除内部病变的机构--免疫系统。免疫的功能可分为先天性免疫和获得性免疫，韩家淮教授的研究重点是在先天性免疫反应中细胞内信号的传导......（更多）

代表性文章：

 1. Zhang DW, Shao J, Lin J, Zhang N, Lu BJ, Lin SC, Dong MQ, Han J. RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science, 325 (5938):332-336, 2009.

 2. Sun P, Yoshizuka N, New L, Moser BA, Li Y, Liao R, Xie C, Chen J, Deng Q, Yamout M, Dong MQ, Frangou CG, Yates JR, 3rd, Wright PE, Han J. PRAK is essential for ras-induced senescence and tumor suppression. Cell, 128 (2):295-308, 2007.

 3. Jing Q, Huang S, Guth S, Zarubin T, Motoyama A, Chen J, Di Padova F, Lin SC, Gram H, Han J.  Involvement of microRNA in AU-rich element-mediated mRNA instability. Cell, 120 (5):623-634, 2005.

 4. Ge B, Gram H, Di Padova F, Huang B, New L, Ulevitch RJ, Luo Y, Han J. MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha. Science, 295 (5558):1291-1294, 2002.

 5. Han J, Jiang Y, Li Z, Kravchenko VV, Ulevitch RJ. Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation. Nature, 386 (6622):296-299, 1997.

 6. Han J, Lee JD, Bibbs L, Ulevitch RJ. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science, 265 (5173):808-811, 1994.

 7. He WT, Wan H, Hu L, Chen P, Wang X, Huang Z, Yang ZH, Zhong CQ, Han J. Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion. Cell Res. 2015 Dec; 25(12): 1285-98. （更多）