316.  X, Han J, Wu J, Silke J. An Overview of Mammalian p38 Mitogen-Activated Protein Kinases, Central Regulators of Cell Stress and Receptor Signaling. F1000Res. . 2020 Jun 29; 9: F1000 Faculty Rev-653.

315. Wang R, Li H, Wu J, Cai ZY, Li B, Ni H, Qiu X, Chen H, Liu W, Yang ZH, Liu M, Hu J, Liang Y, Lan P,  X, Han J, Mo W. Gut Stem Cell Necroptosis by Genome Instability Triggers Bowel Inflammation Nature.  2020 Apr; 580(7803): 386-390.

314. Yang X, Cheng X, Tang Y, Qiu X, Wang Y, Kang H, Wu J, Wang Z, Liu Y, Chen F, Xiao X, Mackman N, Billiar TR,  X, Han J, Lu B. Bacterial Endotoxin Activates the Coagulation Cascade through Gasdermin D-Dependent Phosphatidylserine Exposure. Immunity. 2019 Dec 6. pii: S1074-7613(19)30463-7. doi: 10.1016/j.immuni.2019.11.005. [Epub ahead of print]

313. Zou X, Shi Y, Zhu R,  X, Han J, Han S. Organelle-Redirected Chameleon Sensor-Enabled Live Cell Imaging of Mitochondrial DNA. Anal Chem. 2019 Dec 4. doi: 10.1021/acs.analchem.9b04364. [Epub ahead of print]

312. Zhong CQ, Wu R, Chen X, Wu S, Shuai J,  X, Han J, Systematic assessment of the effect of internal library in targeted analysis of SWATH-MS. J Proteome Res. 2019 Oct 30. doi: 10.1021/acs.jproteome.9b00669. [Epub ahead of print]

311. Lu J, Shi W, Liang B, Chen C, Wu R, Lin H, Zhang Y,  X, Han J, Efficient engulfment of necroptotic and pyroptotic cells by nonprofessional and professional phagocytes. Cell Discov. 2019 Aug 6;5:39. doi: 10.1038/s41421-019-0108-8. eCollection 2019. No abstract available.

310. Shi Y, Zhu R, Xue Z,  X, Han J, Han S. An in cellulo-activated multicolor cell labeling approach used to image dying cell clearance. Analyst. 2019 Aug 7; 144(15): 4687-4693.

309. Ma H, Liu Z, Zhong CQ, Liu Y, Zhang Z, Liang Y, Li J, Han S,  X, Han J, Inactivation of Cyclic AMP Response Element Transcription Caused by Constitutive p38 Activation Is Mediated by Hyperphosphorylation-Dependent CRTC2 Nucleocytoplasmic Transport. Mol Cell Biol. 2019 Apr 16; 39(9). pii: e00554-18. doi: 10.1128/MCB.00554-18. Print 2019 May 1.

308. Zhang X, Fan L, Wu J, Xu H, Leung WY, Fu K, Wu J, Liu K, Man K, Yang  X, Han J, Ren J, Yu J. Macrophage p38α promotes nutritional  steatohepatitis through M1 polarization. J Hepatol. 2019 Mar  23. pii: S0168-8278(19)30184-9. doi: 10.1016/j.jhep.2019.03.014. [Epub ahead of  print]

307. Meng R, Gu L, Lu Y, Zhao K, Wu J, Wang H, Han J, Tang Y, Lu  B. High mobility  group box 1 enables bacterial lipids to trigger receptor-interacting protein  kinase 3 (RIPK3)-mediated necroptosis and apoptosis in mice. J  Biol Chem. 2019 Apr 18. pii: jbc.RA118.007040. doi:  10.1074/jbc.RA118.007040. [Epub ahead of print]

306. Yang D, Liang Y, Zhao S, Ding Y, Zhuang Q, Shi Q, Ai T, Wu SQ, Han  J. ZBP1 mediates  interferon-induced necroptosis. Cell Mol Immunol. 2019 May  10. doi: 10.1038/s41423-019-0237-x. [Epub ahead of print]

305. Wu X, Yang D, Zhao F, Yang ZH, Wang D, Qiao M, Fang Y, Li W, Wu R,  He P, Cong Y, Chen C, Hu L, Yan Y, Xie C, Wu Y, Han J, Zhong CQ. Quantification of dynamic protein  interactions and phosphorylation in LPS signaling pathway by SWATH-MS. Mol Cell Proteomics. 2019 Mar 8. pii: mcp.RA119.001380. doi:  10.1074/mcp.RA119.001380. [Epub ahead of print]

304. Xue Z, Zhao H, Zhu R, Chen C, Cao H, Han J, Han S. On the use of abiotic sialic acids to  attenuate cell inflammation. Sci Rep. 2018 Nov 23; 8(1):  17320.

303. Zhou B, Zhang JY, Liu XS, Chen HZ, Ai YL, Cheng K, Sun RY, Zhou D, Han J, Wu Q. Tom20 senses  iron-activated ROS signaling to promote melanoma cell pyroptosis. Cell  Res. 2018 Dec; 28(12): 1171-1185.

302. Zhu R, Wang S, Xue Z, Han J, Han S. Senescence-associated sialidase  revealed by an activatable fluorescence-on labeling probe. Chem  Commun (Camb). 2018 Oct 11; 54(82): 11566-11569.

301. Xue Z, Wang S, Li J, Chen X, Han J, Han S. Bifunctional Super-resolution Imaging  Probe with Acidity-Independent Lysosome-Retention Mechanism. Anal  Chem. 2018 Oct 2; 90(19): 11393-11400.

300. Su W, Hong L, Xu X, Huang S, Herpai D, Li L, Xu Y, Truong L, Hu WY,  Wu X, Xiao C, Zhang W, Han J, Debinski W, Xiang R, Sun P. miR-30 disrupts senescence and  promotes cancer by targeting both p16INK4A and DNA damage pathways. Oncogene.  2018 Oct; 37(42): 5618-5632.

299. Xue Z, Zhang E, Liu J, Han J, Han S. Bioorthogonal Conjugation Directed by  a Sugar-Sorting Pathway for Continual Tracking of Stressed Organelles. Angew Chem Int Ed Engl. 2018 Aug 6; 57(32):  10096-10101.  

298. Qiu X, Zhang Y, Han J. RIP3 is an upregulator of aerobic  metabolism and the enhanced respiration by necrosomal RIP3 feeds back on  necrosome to promote necroptosis. Cell Death Differ. 2018 Mar  9. doi: 10.1038/s41418-018-0075-x. [Epub ahead of print]

297. Xue Z, Zhu R, Wang S, Li J, Han J, Liu J, Han S. Organelle-Directed Staudinger  Reaction Enabling Fluorescence-on Resolution of Mitochondrial Electropotentials  via a Self-Immolative Charge Reversal Probe. Anal Chem. 2018  Feb 20;90(4):2954-2962.

296. Yang Z, Wang Y, Zhang Y, He X, Zhong CQ, Ni H, Chen X, Liang Y, Wu  J, Zhao S, Zhou D, Han J. RIP3 targets pyruvate dehydrogenase  complex to increase aerobic respiration in TNF-induced necroptosis. Nat  Cell Biol. 2018 Feb; 20(2): 186-197.

295. Yang Z, Wang Y, Zhang  Y, He X, Zhong CQ, Ni H, Chen X, Liang Y, Wu J, Zhao S, Zhou D, Han J. RIP3 targets pyruvate dehydrogenase  complex to increase aerobic respiration in TNF-induced necroptosis. Nat  Cell Biol. 2018 Jan 22. doi: 10.1038/s41556-017-0022-y. [Epub ahead of  print]

294. Zhang Y, Chen X,  Gueydan C, Han J. Plasma  membrane changes during programmed cell deaths. Cell Res. 2017  Oct 27. doi: 10.1038/cr.2017.133. [Epub ahead of print]

293. Lin KC, Moroishi T,  Meng Z, Jeong HS, Plouffe SW, Sekido Y, Han J, Park HW, Guan KL. Regulation of Hippo pathway  transcription factor TEAD by p38 MAPK-induced cytoplasmic translocation. Nat Cell Biol. 2017 Jul 28; 19(8): 996-1002.

292. Xue Z, Zhao H, Liu J, Han  J, Han S. Imaging  Lysosomal pH Alteration in Stressed Cells with a Sensitive Ratiometric  Fluorescence Sensor. ACS Sens. 2017 Mar  24;2(3):436-442.

291. Zhang Z, Meszaros G, He  WT, Xu Y, de Fatima Magliarelli H, Mailly L, Mihlan M, Liu Y, Puig Gámez M,  Goginashvili A, Pasquier A, Bielska O, Neven B, Quartier P, Aebersold R,  Baumert TF, Georgel P, Han J, Ricci R. Protein kinase D at the Golgi  controls NLRP3 inflammasome activation. J Exp Med. 2017 Sep  4; 214(9): 2671-2693.

290. Ren J, Jia X, Zhao Y,  Shi W, Lu J, Zhang Y, Wu J, Liang B, Wu R, Fu G, Han J. The RIP3-RIP1-NF-κB signaling axis is  dispensable for necroptotic cells to elicit cross-priming of CD8+ T cells. Cell Mol Immunol. 2017 Jul; 14(7): 639-642.

289. Xue Z, Zhao H, Liu J, Han  J, Han S. Defining  Cancer Cell Bioenergetic Profiles Using a Dual Organelle-Oriented Chemosensor  Responsive to pH Values and Electropotential Changes. Anal Chem. 2017 Jul 18;89(14):7795-7801.

288. Yang Z, Jiang B, Wang  Y, Ni H, Zhang J, Xia J, Shi M, Hung LM, Ruan J, Mak TW, Li Q, Han J. 2-HG Inhibits Necroptosis by  Stimulating DNMT1-Dependent Hypermethylation of the RIP3 Promoter. Cell  Rep. 2017 May 30;19(9):1846-1857. doi: 10.1016/j.celrep.2017.05.012.

287. Geng J, Yu S, Zhao H,  Sun X, Li X, Wang P, Xiong X, Hong L, Xie C, Gao J, Shi Y, Peng J, Johnson RL,  Xiao N, Lu L, Han J, Zhou D, Chen L. The transcriptional coactivator TAZ  regulates reciprocal differentiation of TH17 cells and Treg cells. Nat Immunol. 2017 May 15. doi: 10.1038/ni.3748. [Epub ahead of print]

286. Xue Z, Zhao H, Liu J, Han  J, Han S. Responsive  hetero-organelle partition conferred fluorogenic sensing of mitochondrial  depolarization. Chem Sci. 2017 Mar 1;8(3):1915-1921. doi:  10.1039/c6sc04158b. Epub 2016 Nov 8.

285. Jin HY, Oda H, Chen P,  Yang C, Zhou X, Kang SG, Valentine E, Kefauver J, Liao L, Zhang Y,  Gonzalez-Martin A, Shepherd J, Morgan GJ, Mondala TS, Head SR, Kim PH, Xiao N,  Fu G, Liu WH, Han J, Williamson JR, Xiao C. Differential Sensitivity of Target  Genes to Translational Repression by miR-17~92. PLoS Genet. 2017 Feb 27;13(2):e1006623.

284. Zhang Y, Su SS, Zhao S,  Yang Z, Zhong CQ, Chen X, Cai Q, Yang ZH, Huang D, Wu R, Han J. RIP1 autophosphorylation is promoted  by mitochondrial ROS and is essential for RIP3 recruitment into necrosome. Nat Commun. 2017 Feb 8; 8: 14329. doi: 10.1038/ncomms14329.

283. Huang D, Zheng X, Wang  ZA, Chen X, He WT, Zhang Y, Xu JG, Zhao H, Shi W, Wang X, Zhu Y, Han J. MLKL channel in necroptosis is  octamer formed by tetramers in a dyadic process. Mol Cell Biol. 2017 Feb 15; 37(5).

282. Yoshikawa T, Wu J,  Otsuka M, Kishikawa T, Suzuki N, Takata A, Ohno M, Ishibashi R, Yamagami M,  Nakagawa R, Kato N, Miyazawa M, Han J, Koike K. Repression of microRNA Function  Mediates Inflammation-associated Colon Tumorigenesis. Gastroenterology. 2017 Feb; 152(3): 631-643.

281. Zhou Y, Wu J, Liu C,  Guo X, Zhu X, Yao Y, Jiao Y, He P, Han J, Wu L. p38α has an important role in antigen  cross-presentation by dendritic cells. Cell Mol Immunol. 2016  Nov 21. doi: 10.1038/cmi.2016.49. [Epub ahead of print]

280. Chen X, He WT, Hu L, Li  J, Fang Y, Wang X, Xu X, Wang Z, Huang K, Han J. Pyroptosis is driven by non-selective  gasdermin-D pore and its morphology is different from MLKL channel-mediated  necroptosis. Cell Res. 2016 Sep;26(9):1007-20.

279. Xu Y, Han J. The Necrosome in Acute Kidney Injury. Semin Nephrol. 2016 May; 36(3): 199-207.

278. Zhang Y, Han J. Electrophysiologist shows a cation  channel function of MLKL. Cell Res. 2016 Jun; 26(6): 643-4.

277. Ma H, Pan JS, Jin LX,  Wu J, Ren YD, Chen P, Xiao C, Han J. MicroRNA-17~92 inhibits colorectal  cancer progression by targeting angiogenesis. Cancer Lett. 2016  Jul 1; 376(2): 293-302.

276. Wang XD, Gong Y, Chen  ZL, Gong BN, Xie JJ, Zhong CQ, Wang QL, Diao LH, Xu A, Han J, Altman A,  Li Y. TCR-induced  sumoylation of the kinase PKC-θ controls T cell synapse organization and T cell  activation. Nat Immunol. 2015 Nov; 16(11): 1195-203.

275.  He WT, Wan H, Hu L, Chen P, Wang X, Huang Z, Yang ZH, Zhong CQ, Han J. Gasdermin D is an executor of  pyroptosis and required for interleukin-1β secretion. Cell Res. 2015 Dec; 25(12): 1285-98.

274. Zheng, M.Xie, L.Liang, Y.Wu, S.Xu, H.Zhang, Y.Liu, H.Lin, D.Han, J.Lu, K.               Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation. Nat Chem Biol 2015 Apr 5;11(5):587-94. doi: 10.7150/ijbs.10945.

273. Yoshikawa, T.Wu, J.Otsuka, M.Kishikawa, T.Ohno, M.Shibata, C.Takata, A.Han, F.Kang, Y. J. Chen, C. Y.Shyu, A. B.Han, J.Koike, K.  ROCK inhibition enhances microRNA function by promoting deadenylation of targeted mRNAs via increasing PAIP2 expression. Nucleic Acids Res. 2015 Sep 3;43(15):7577-89. doi: 10.1093/nar/gkv728. Epub 2015 Jul 17.

272. Xu, Y.Ma, H.Shao, J.Wu, J.Zhou, L.Zhang, Z.Wang, Y.Huang, Z.Ren, J.Liu, S.Chen, X.Han, J.   A Role for Tubular Necroptosis in Cisplatin-Induced AKI. J Am Soc Nephrol  2015 Mar 18. pii: ASN.2014080741.

271. Xie, W., Zhang, L., Jiao, H., Guan, L., Zha, J., Li, X., Wu, M., Wang, Z., Han, J., and You, H.  Chaperone-mediated autophagy prevents apoptosis by degrading BBC3/PUMA. Autophagy.   2015 Sep 2;11(9):1623-35. doi: 10.1080/15548627.2015.1075688.

270. Wu, X.J., Yu, M.Z., Lin, B.J., Xing, H.J., Han, J.H., and Han, S.F.  A sialic acid-targeted near-infrared theranostic for signal activation based intraoperative tumor ablation Chem Sci. 2015,6, 798-803. doi:10.1039/C4SC02248C

269. Wu, X.J., Lin, B.J., Yu, M.Z., Yang, L., Han, J.H., and Han, S.F.  A carbohydrate-grafted nanovesicle with activatable optical and acoustic contrasts for dual modality high performance tumor imaging Chem Sci. 2015,6,2002-2009. doi:10.1039/C4SC03641G

268. Wei, X.Shao, B.He, Z.Ye, T.Luo, M.Sang, Y.Liang, X.Wang, W.Luo, S.Yang, S.Zhang, S.Gong, C.Gou, M.Deng, H.Zhao, Y.Yang, H.Deng, S.Zhao, C.Yang, L.Qian, Z.Li, J.Sun, X.Han, J.Jiang, C.Wu, M.Zhang, Z.  Cationic nanocarriers induce cell necrosis through impairment of Na(+)/K(+)-ATPase and cause subsequent inflammatory response. Cell Res.  2015 Feb;25(2):237-53. doi: 10.1038/cr.2015.9. Epub 2015 Jan 23.

267. Tian, Y., Yu, M., Li, Z., Han, J., Yang, L., and Han, S.  Optical Tracking of Phagocytosis with an Activatable Profluorophore Metabolically Incorporated into Bacterial Peptidoglycan Anal Chem. 2015 Aug 18;87(16):8381-6. doi:10.1021/acs.analchem.5b01633. Epub 2015 Aug 5.

266. Li, Y., Zhong, C.Q., Xu, X., Cai, S., Wu, X., Zhang, Y., Chen, J., Shi, J., Lin, S., and Han, J.  Group-DIA: analyzing multiple data-independent acquisition mass spectrometry data files. Nat Methods. Nat Methods. 2015 Oct 5. doi: 10.1038/nmeth.3593.

265. Zheng, M., Xie, L., Liang, Y., Wu, S., Xu, H., Zhang, Y., Liu, H., Lin, D., Han, J., and Lu, K. (2015). Recognition of cytosolic DNA attenuates glucose metabolism and induces AMPK mediated energy stress response. Int J Biol Sci., 2015 Mar 31;11(5):587-594. doi:10.7150/ijbs.10945

264. Chen F, Lin X, Xu P, Zhang Z, Chen Y, Wang C, Han J, Zhao B, Xiao M, Feng XH. Nuclear Export of Smads by RanBP3L Regulates BMP Signaling and Mesenchymal Stem Cell Differentiation. Mol Cell Biol. 2015 Mar 9. pii: MCB.00121-15. [Epub ahead of print]

263. Chen W, Wu J, Li L, Zhang Z, Ren J, Liang Y, Chen F, Yang C, Zhou Z, Sean Su S, Zheng X, Zhang Z, Zhong CQ, Wan H, Xiao M, Lin X, Feng XH, Han J. Ppm1b negatively regulates necroptosis through dephosphorylating Rip3. Nat Cell Biol. 2015 Mar 9. doi: 10.1038/ncb3120. [Epub ahead of print]

262. Huang Z, Wu SQ, Liang Y, Zhou X, Chen W, Li L, Wu J, Zhuang Q, Chen C, Li J, Zhong CQ, Xia W, Zhou R, Zheng C, Han J. RIP1/RIP3 Binding to HSV-1 ICP6 Initiates Necroptosis to Restrict Virus Propagation in Mice. Cell Host Microbe. 2015 Feb 11;17(2):229-42. doi: 10.1016/j.chom.2015.01.002.

261. Wei X, Shao B, He Z, Ye T, Luo M, Sang Y, Liang X, Wang W, Luo S, Yang S, Zhang S, Gong C, Gou M, Deng H, Zhao Y, Yang H, Deng S, Zhao C, Yang L, Qian Z, Li J, Sun X, Han J, Jiang C, Wu M, Zhang Z. Cationic nanocarriers induce cell necrosis through impairment of Na+/K+-ATPase and cause subsequent inflammatory response. Cell Res. 2015 Jan 23. doi: 10.1038/cr.2015.9. [Epub ahead of print]

260. Yang M, Shao J, Miao Y, Cui W, Qi Y, Han J, Lin X, Du J. Tumor cell-activated CARD9 signaling contributes to metastasis-associated macrophage polarization. Cell Death Differ. 2014; 21(8): 1290-302.

259. Wang X, Jiang W, Yan Y, Gong T, Han J, Tian Z, Zhou R. RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway. Nat Immunol. 2014 Oct 19. doi: 10.1038/ni.3015. [Epub ahead of print]

258. Xu H, Xue Z, Han J, Su X, Han S. Centrifugation aided highly sensitive detection of nitrite with a dye-silica conjugate featuring cleavable linkages. Bioorg Med Chem Lett. 2014 Sep 3. pii: S0960-894X(14)00895-6. doi: 10.1016/j.bmcl.2014.08.051. [Epub ahead of print]

257. Tian L, Chen J, Chen M,  Gui C, Zhong CQ, Hong L, Xie C, Wu X, Yang L, Ahmad V, Han J. The p38 pathway Regulates Oxidative  Stress Tolerance by Phosphorylation of Mitochondrial Protein IscU. J  Biol Chem. 2014 Sep 9. pii: jbc.M114.589093. [Epub ahead of print]

256. Zhang CS, Jiang B, Li  M, Zhu M, Peng Y, Zhang YL, Wu YQ, Li TY, Liang Y, Lu Z, Lian G, Liu Q, Guo H,  Yin Z, Ye Z, Han J, Wu JW, Yin H, Lin SY, Lin SC.Common Activator for AMPK and mTORC1, Acting as a Switch between  Catabolism and Anabolism. Cell Metab. 2014 Jul 4. pii:  S1550-4131(14)00279-4. doi: 10.1016/j.cmet.2014.06.014. [Epub ahead of print]

255. Wu S, Han S, Han J,  Su X. A  photothermal cell viability-reporting theranostic nanoprobe for intraoperative  optical ablation and tracking of tumors. Chem Commun (Camb).  2014 Jun 11. [Epub ahead of print]

254.Wu XN, Yang ZH, Wang XK, Zhang Y, Wan H, Song Y, Chen  X, Shao J, Han J. Distinct  roles of RIP1-RIP3 hetero- and RIP3-RIP3 homo-interaction in mediating  necroptosis. Cell Death and Differentiation. 2014 Jun 6. doi:  10.1038/cdd.2014.77. [Epub ahead of print]

253. Zaidi SK, Shen WJ,  Bittner S, Bittner A, McLean MP, Han J, Davis RJ, Kraemer FB, Azhar S. p38 MAPK regulates steroidogenesis  through transcriptional repression of StAR gene. J Mol Endocrinol.  2014 Apr 29. [Epub ahead of print]

252. Wu T, Li Y, Huang D,  Han F, Zhang YY, Zhang DW, Han J. Regulator of G-Protein Signaling 19  (RGS19) and Its Partner Gα-Inhibiting Activity Polypeptide 3 (GNAI3) Are  Required for zVAD-Induced Autophagy and Cell Death in L929 Cells. PLoS  One. 2014; 9(4): e94634.

251. Wu X, He WT, Tian S,  Meng D, Li Y, Chen W, Li L, Tian L, Zhong CQ, Han F, Chen J, Han J. pelo Is  Required for High Efficiency Viral Replication. PLoS Pathog.  2014; 10(4): e1004034.

250. Li Z, Wu S, Han J,  Yang L, Han S. Resolution of lysosomes in living cells with a ratiometric molecular  pH-meter. Talanta. 2013; 114: 254-60.

249. Qiu SL, Xiao ZC, Piao  CM, Xian YL, Jia LX, Qi YF, Han J, Zhang YY, Du J. AMP-Activated Protein Kinase α2  Protects Against Liver Injury from Metastasized Tumors via Reduced Glucose  Deprivation-Induced Oxidative Stress. J Biol Chem. 2014; 289(13):  9449-59.

248. Li L, Chen W, Liang Y,  Ma H, Li W, Zhou Z, Li J, Ding Y, Ren J, Lin J, Han F, Wu J, Han J. The Gβγ-Src signaling pathway  regulates TNF-induced necroptosis via control of necrosome translocation. Cell Res. 2014; 24(4): 417-32.

247. Zhong CQ, Li Y, Yang D,  Zhang N, Xu X, Wu Y, Chen J, Han J. Quantitative Phosphoproteomic  Analysis of RIP3-dependent Protein Phosphorylation in the Course of TNF-induced  Necroptosis. Proteomics. 2014; 14(6): 713-24.

246. Li H, Zhuang Q, Wang Y,  Zhang T, Zhao J, Zhang Y, Zhang J, Lin Y, Yuan Q, Xia N, Han J. HBV life cycle is restricted in mouse  hepatocytes expressing human NTCP. Cell Mol Immunol. 2014; 11(2):  175-83.

245. Shi S, Lin J, Cai Y, Yu  J, Hong H, Ji K, Downey JS, Lu X, Chen R, Han J, Han A. Dimeric  structure of p300/CBP associated factor. BMC Struct Biol. 2014; 14(1): 2.

244. Chen X, Li W, Ren J,  Huang D, He WT, Song Y, Yang C, Li W, Zheng X, Chen P, Han J. Translocation of mixed lineage kinase  domain-like protein to plasma membrane leads to necrotic cell death. Cell Res. 2013; 24(1):105-21.

243. Wang WJ, Wang Y, Chen  HZ, Xing YZ, Li FW, Zhang Q, Zhou B, Zhang HK, Zhang J, Bian XL, Li L, Liu Y,  Zhao BX, Chen Y, Wu R, Li AZ, Yao LM, Chen P, Zhang Y, Tian XY, Beermann F, Wu  M, Han J, Huang PQ, Lin T, Wu Q. Orphan  nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling  pathway. Nat Chem Biol. 2013; 10(2):133-40.

242. Wu X, Shi J, Yang L, Han  J, Han S. A near-infrared fluorescence dye for sensitive detection of hydrogen  sulfide in serum. Bioorg Med Chem Lett. 2014; 24(1): 314-6.

241. Zheng J, Yang M, Shao  J, Miao Y, Han J, Du J. Chemokine  receptor CX3CR1 contributes to macrophage survival in tumor metastasis. Mol Cancer. 2013; 12(1): 141.

240. Liu X, Xiao W, Wang XD,  Li YF, Han J, Li Y. The p38-Interacting Protein (p38IP) Regulates G2/M Progression by  Promoting α-tubulin Acetylation via Inhibiting Ubiquitination-induced  Degradation of the Acetyltransferase GCN5. J Biol Chem. 2013;  288(51): 36648-61.

239. Zhang YL, Guo H, Zhang  CS, Lin SY, Yin Z, Peng Y, Luo H, Shi Y, Lian G, Zhang C, Li M, Ye Z, Ye J, Han  J,Li P, Wu JW, Lin SC. AMP as a Low-Energy Charge Signal Autonomously  Initiates Assembly of AXIN-AMPK-LKB1 Complex for AMPK Activation. Cell  Metab. 2013; 18(4): 546-555.

238. Jiang W, Wang X, Zeng  B, Liu L, Tardivel A, Wei H, Han J, Macdonald HR, Tschopp J, Tian Z,  Zhou R. Recognition  of gut microbiota by NOD2 is essential for the homeostasis of intestinal  intraepithelial lymphocytes. J Exp Med. 2013; 210(11): 2465-76.

237. Ma J, Bang BR, Lu J,  Eun SY, Otsuka M, Croft M, Tobias P, Han J, Takeuchi O, Akira S, Karin  M, Yagita H, Kang YJ. The TNF Family Member 4-1BBL Sustains Inflammation by Interacting with  TLR Signaling Components During Late-Phase Activation. Sci  Signal. 2013; 6(295): ra87.

236. Shao J, Teng Y, Padia R, Hong  S, Noh H, Xie X, Mumm JS, Dong Z, Ding HF, Cowell J, Kim J, Han J, Huang  S. COP1 and  GSK3β Cooperate to Promote c-Jun Degradation and Inhibit Breast Cancer Cell  Tumorigenesis. Neoplasia. 2013; 15(9): 1075-85.

235. Chen X, Wu S, Han  J, Han S. Rhodamine-propargylic esters for detection of mitochondrial hydrogen  sulfide in living cells. Bioorg Med Chem Lett. 2013; 23(19): 5295-9.

234. Shim EJ, Bang BR,  Kang SG, Ma J, Otsuka M, Kang J, Stahl M, Han J, Xiao C, Vallance BA,  Kang YJ. Activation of  p38α in T Cells Regulates the Intestinal Host Defense against Attaching and  Effacing Bacterial Infections. J Immunol. 2013; 191(5):2764-70.

233. Wu J, Huang Z, Ren J,  Zhang Z, He P, Li Y, Ma J, Chen W, Zhang Y, Zhou X, Yang Z, Wu SQ, Chen L, Han  J. Mlkl knockout  mice demonstrate the indispensable role of Mlkl in necroptosis. Cell  Res. 2013; 23(8): 994-1006.

232. Wu Z, Wu X, Li Z,  Yang Y, Han J, Han S. Benzothiazoline based chemodosimeters  for fluorogenic detection of hypochlorous acid. Bioorg Med Chem  Lett. 2013; 23(15): 4354-7.

231. Lu J, Wu X, Hong M,  Tobias P, Han J. A Potential  Suppressive Effect of Natural Antisense IL-1β RNA on Lipopolysaccharide-Induced  IL-1β Expression. J Immunol. 2013; 190(12): 6570-8.

230. Chen W, Zhou Z, Li L,  Zhong CQ, Zheng X, Wu X, Zhang Y, Ma H, Huang D, Li W, Xia Z, Han J. Diverse Sequence Determinants Control  Human and Mouse Receptor Interacting Protein 3 (RIP3) and Mixed Lineage Kinase  domain-Like (MLKL) Interaction in Necroptotic Signaling. J Biol  Chem. 2013; 288(23): 16247-61.

229. Zhang Z, Xu X, Ma J,  Wu J, Wang Y, Zhou R, Han J. Gene Deletion  of Gabarap Enhances Nlrp3 Inflammasome-Dependent Inflammatory Responses. J Immunol. 2013; 190(7): 3517-24.

228. Lin J, Li H, Yang M, Ren J, Huang Z, Han F, Huang J, Ma J, Zhang D, Zhang Z, Wu J, Huang D, Qiao M, Jin G, Wu Q, Huang Y, Du J,Han J. A Role of RIP3-Mediated Macrophage Necrosis in Atherosclerosis Development. Cell Rep. 2013 Jan 16. doi:pii: S2211-1247(12)00457-3. 10.1016/j.celrep.2012.12.012. [Epub ahead of print]

227. Wang RH, He JP, Su ML, Luo J, Xu M, Du XD, Chen HZ, Wang WJ, Wang Y, Zhang N, Zhao BX, Zhao WX, Shan ZG, Han J, Chang C, Wu Q. The orphan receptor TR3 participates in angiotensin II-induced cardiac hypertrophy by controlling mTOR signalling. EMBO Mol Med. 2012 Nov 29. doi: 10.1002/emmm.201201369. [Epub ahead of print]

226. Wu X, Tian L, Li J, Zhang Y, Han V, Li Y, Xu X, Li H, Chen X, Chen J, Jin W, Xie Y, Han J, Zhong CQ. Investigation of RIP3-dependent protein phosphorylation by quantitative phosphoproteomics. Mol Cell Proteomics. 2012; 11(12): 1640-51.

225. Xuanjun Wu, Zhu Li, Yuhui Yang, Liu Yang, Han J and Shoufa Han. A self-referenced nanodosimeter for reaction based ratiometric detection of hypochlorous acid in living cells. Chem. Sci., 2013, 4, 460-467

224. Zhu Li, Yunlong Song, Yuhui Yang, Liu Yang, Xiaohong Huang, Han J and Shoufa Han. Rhodamine-deoxylactam functionalized poly[styrene-alter-(maleic acid)] as lysosome activatable probes for intraoperative detection of tumors. Chem. Sci. 2012, 2941-2948.

223. Wu Z, Li Z, Yang L, Han J, Han S. Cytosolic delivey of proteins mediated by aldehyde-displaying silica nanoparticles with pH responsive characteristics. Chem Commun (Camb). 2012; 48(81):10120-2.

222. Wu Z, Li Z, Yang L, Han J, Han S. Fluorogenic detection of hydrogen sulfide via reductive unmasking of o-azidomethylbenzoyl-coumarin conjugate. Chem Commun (Camb), 2012, 48, 10120-10122

221. Zhou Z, Han V, Han J. New components of the necroptotic pathway. Protein Cell. 2012; 3(11): 811-7.

220. Li H, Ye C, Ji G, Wu X, Xiang Z, Li Y, Cao Y, Liu X, Douek DC, Price DA, Han J. Recombinatorial Biases and Convergent Recombination Determine Interindividual TCRβ Sharing in Murine Thymocytes. J Immunol. 2012;189(5):2404-13.

219. Lin SY, Li TY, Liu Q, Zhang C, Li X, Chen Y, Zhang SM, Lian G, Liu Q, Ruan K, Wang Z, Zhang CS, Chien KY, Wu J, Li Q, Han J, Lin SC. Protein phosphorylation-acetylation cascade connects growth factor deprivation to autophagy. Autophagy. 2012; 8(9):1385-6.

218. Zhang T, Cheng T, Wei L, Cai Y, Yeo AE, Han J, Yuan YA, Zhang J, Xia N. Efficient inhibition of HIV-1 replication by an artificial polycistronic miRNA construct. Virol J. 2012; 9(1): 118.

217. Shuqi Wu, Yunlong Song, Zhu Li, Zhisheng Wu, Han J and Shoufa Han. Covalent labeling of mitochondria with a photostable fluorescent thiol-reactive rhodamine-based probe. Anal. Methods. 2012; 4, 1699-1703

216. Yoshizuka N, Lai M, Liao R, Cook R, Xiao C, Han J, Sun P. PRAK Suppresses Oncogenic ras-Induced Hematopoietic Cancer Development by Antagonizing the JNK Pathway. Mol Cancer Res. 2012; 10(6): 810-20.

215. Lin SY, Li TY, Liu Q, Zhang C, Li X, Chen Y, Zhang SM, Lian G, Liu Q, Ruan K, Wang Z, Zhang CS, Chien KY, Wu J, Li Q, Han J, Lin SC. GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy. Science. 2012; 336(6080):477-81.

214. Zhu M, Yuan H, Guo W, Li X, Jin L, Brunk UT, Han J, Zhao M, Lu Y. Dietary Mustard Seeds (Sinapis alba Linn) Suppress 1,2-Dimethylhydrazine-Induced Immuno-Imbalance and Colonic Carcinogenesis in Rats. Nutr Cancer. 2012. 64(3): 464-72.

213. Li H, Ye C, Ji G, Han J. 2012. Determinants of public T cell responses. Cell Res 22: 33-42

212. Yoshizuka N, Chen RM, Xu Z, Liao R, Hong L, Hu WY, Yu G, Han J, Chen L, Sun P. 2011. A Novel Function of p38-Regulated/Activated Kinase (PRAK) In Endothelial Cell Migration and Tumor Angiogenesis. Mol Cell Biol

211. Han J, Zhong CQ, Zhang DW. 2011. Programmed necrosis: backup to and competitor with apoptosis in the immune system. Nat Immunol 12: 1143-9

210. Wu S, Li Z, Han J, Han S. 2011. Dual colored mesoporous silica nanoparticles with pH activable rhodamine-lactam for ratiometric sensing of lysosomal acidity. Chemical communications 47: 11276-8

209. Li Z, Xue Z, Wu Z, Han J, Han S. 2011. Chromo-fluorogenic detection of aldehydes with a rhodamine based sensor featuring an intramolecular deoxylactam. Organic & biomolecular chemistry

208. Li Z, Wu S, Han J, Han S. 2011. Imaging of intracellular acidic compartments with a sensitive rhodamine based fluorogenic pH sensor.The Analyst 136: 3698-706

207. Wu XN, Wang XK, Wu SQ, Lu J, Zheng M, Wang YH, Zhou H, Zhang H, Han J. 2011. Phosphorylation of Raptor by p38beta participates in arsenite-induced mammalian target of rapamycin complex 1 (mTORC1) activation. The Journal of biological chemistry 286: 31501-11

206. Lee S, Wang Y, Kim SO, Han J. 2011. AMPD3 is involved in anthrax LeTx-induced macrophage cell death. Protein & cell 2: 564-72

205. Ono K, Kuwabara Y, Han J. 2011. MicroRNAs and cardiovascular diseases. The FEBS journal 278: 1619-33

204. Seit-Nebi A, Cheng W, Xu H, Han J. 2011. MLK4 has negative effect on TLR4 signaling. Cellular & molecular immunology

203. Zheng M, Wang YH, Wu XN, Wu SQ, Lu BJ, Dong MQ, Zhang H, Sun P, Lin SC, Guan KL, Han J. 2011. Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1. Nature cell biology 13: 263-72

202. Zhang DW, Zheng M, Zhao J, Li YY, Huang Z, Li Z, Han J. 2011. Multiple death pathways in TNF-treated fibroblasts: RIP3- and RIP1-dependent and independent routes. Cell research 21: 368-71

201. Diao Y, Liu W, Wong CC, Wang X, Lee K, Cheung PY, Pan L, Xu T, Han J, Yates JR, 3rd, Zhang M, Wu Z. 2010. Oxidation-induced intramolecular disulfide bond inactivates mitogen-activated protein kinase kinase 6 by inhibiting ATP binding. Proceedings of the National Academy of Sciences of the United States of America 107: 20974-9

200. Chen J, Xie C, Tian L, Hong L, Wu X, Han J. 2010. Participation of the p38 pathway in Drosophila host defense against pathogenic bacteria and fungi. Proceedings of the National Academy of Sciences of the United States of America 107: 20774-9

199. Hong L, Lai M, Chen M, Xie C, Liao R, Kang YJ, Xiao C, Hu WY, Han J, Sun P. 2010. The miR-17-92 cluster of microRNAs confers tumorigenicity by inhibiting oncogene-induced senescence. Cancer research 70: 8547-57

198. Zhou H, Chen J, Han J. 2010. Activation of p38 and determination of its activity. Methods in molecular biology 661: 75-89

197. Martins A, Han J, Kim SO. 2010. The multifaceted effects of granulocyte colony-stimulating factor in immunomodulation and potential roles in intestinal immune homeostasis. IUBMB life 62: 611-7

196. Wang S, Huang Q, Guo X, Brunk UT, Han J, Zhao K, Zhao M. 2010. The P38alpha and P38delta MAP kinases may be gene therapy targets in the future treatment of severe burns. Shock34: 176-82

195. Zhang D, Lin J, Han J. 2010. Receptor-interacting protein (RIP) kinase family. Cellular & molecular immunology 7: 243-9

194. Kang YJ, Otsuka M, van den Berg A, Hong L, Huang Z, Wu X, Zhang DW, Vallance BA, Tobias PS, Han J. 2010. Epithelial p38alpha controls immune cell recruitment in the colonic mucosa. PLoS pathogens6: e1000934

193. Wu CC, Wu X, Han J, Sun P. 2010. p38gamma regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage.Protein & cell 1: 573-83

192. Ota A, Zhang J, Ping P, Han J, Wang Y. 2010. Specific regulation of noncanonical p38alpha activation by Hsp90-Cdc37 chaperone complex in cardiomyocyte. Circulation research106: 1404-12

191. Wang L, Gordon RA, Huynh L, Su X, Park Min KH, Han J, Arthur JS, Kalliolias GD, Ivashkiv LB. 2010. Indirect inhibition of Toll-like receptor and type I interferon responses by ITAM-coupled receptors and integrins. Immunity32: 518-30

190. Otsuka M, Kang YJ, Ren J, Jiang H, Wang Y, Omata M, Han J. 2010. Distinct effects of p38alpha deletion in myeloid lineage and gut epithelia in mouse models of inflammatory bowel disease. Gastroenterology138: 1255-65, 65 e1-9

189. Huang P, Han J, Hui L. 2010. MAPK signaling in inflammation-associated cancer development. Protein & cell 1: 218-26

188. Ono K, Wang X, Kim SO, Armstrong LC, Bornstein P, Han J. 2010. Metaxin deficiency alters mitochondrial membrane permeability and leads to resistance to TNF-induced cell killing. Protein & cell 1: 161-73

187. Ma J, Meng Y, Kwiatkowski DJ, Chen X, Peng H, Sun Q, Zha X, Wang F, Wang Y, Jing Y, Zhang S, Chen R, Wang L, Wu E, Cai G, Malinowska-Kolodziej I, Liao Q, Liu Y, Zhao Y, Xu K, Dai J, Han J, Wu L, Zhao RC, Shen H, Zhang H. 2010. Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade. The Journal of clinical investigation120: 103-14

186. Li Q, Lin S, Wang X, Lian G, Lu Z, Guo H, Ruan K, Wang Y, Ye Z, Han J, Lin SC. 2009. Axin determines cell fate by controlling the p53 activation threshold after DNA damage. Nature cell biology 11: 1128-34

185. Zhang DW, Shao J, Lin J, Zhang N, Lu BJ, Lin SC, Dong MQ, Han J. 2009. RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science325: 332-6

184. Su R, Li L, Chen X, Han J, Han S. 2009. Multivalent mannose-displaying nanoparticles constructed from poly{styrene-co-[(maleic anhydride)-alt-styrene]}. Organic & biomolecular chemistry 7: 2040-5

183. Kwong J, Hong L, Liao R, Deng Q, Han J, Sun P. 2009. p38alpha and p38gamma mediate oncogenic ras-induced senescence through differential mechanisms. The Journal of biological chemistry 284: 11237-46

182. Fang W, Cai Y, Chen X, Su R, Chen T, Xia N, Li L, Yang Q, Han J, Han S. 2009. Poly(styrene-alt-maleic anhydride) derivatives as potent anti-HIV microbicide candidates. Bioorganic & medicinal chemistry letters19: 1903-7

181. Nagy Z, Riss A, Romier C, le Guezennec X, Dongre AR, Orpinell M, Han J, Stunnenberg H, Tora L. 2009. The human SPT20-containing SAGA complex plays a direct role in the regulation of endoplasmic reticulum stress-induced genes. Molecular and cellular biology29: 1649-60

180. Ren JL, Pan JS, Lu YP, Sun P, Han J. 2009. Inflammatory signaling and cellular senescence. Cellular signalling21: 378-83

179. Hu X, Chung AY, Wu I, Foldi J, Chen J, Ji JD, Tateya T, Kang YJ, Han J, Gessler M, Kageyama R, Ivashkiv LB. 2008. Integrated regulation of Toll-like receptor responses by Notch and interferon-gamma pathways. Immunity29: 691-703

178. Mols J, van den Berg A, Otsuka M, Zheng M, Chen J, Han J. 2008. TNF-alpha stimulation inhibits siRNA-mediated RNA interference through a mechanism involving poly-(A) tail stabilization. Biochimica et biophysica acta1779: 712-9

177. van den Berg A, Mols J, Han J. 2008. RISC-target interaction: cleavage and translational suppression. Biochimica et biophysica acta1779: 668-77

176. Abidi P, Zhang H, Zaidi SM, Shen WJ, Leers-Sucheta S, Cortez Y, Han J, Azhar S. 2008. Oxidative stress-induced inhibition of adrenal steroidogenesis requires participation of p38 mitogen-activated protein kinase signaling pathway. The Journal of endocrinology198: 193-207

175. Ha SD, Martins A, Khazaie K, Han J, Chan BM, Kim SO. 2008. Cathepsin B is involved in the trafficking of TNF-alpha-containing vesicles to the plasma membrane in macrophages. Journal of immunology181: 690-7

174. Zhang T, Cheng T, Zhang YL, Wei LH, Cai YJ, Zhang J, Zhu H, Han J, Xia NS. 2008. [Screening of highly effective siRNA sequence targeting to HIV-1 vif and the lentiviral-mediated antiviral research in vitro]. Bing du xue bao = Chinese journal of virology / [bian ji, Bing du xue bao bian ji wei yuan hui] 24: 88-95

173. Zhuang S, Kinsey GR, Yan Y, Han J, Schnellmann RG. 2008. Extracellular signal-regulated kinase activation mediates mitochondrial dysfunction and necrosis induced by hydrogen peroxide in renal proximal tubular cells. The Journal of pharmacology and experimental therapeutics325: 732-40

172. Otsuka M, Zheng M, Hayashi M, Lee JD, Yoshino O, Lin S, Han J. 2008. Impaired microRNA processing causes corpus luteum insufficiency and infertility in mice. The Journal of clinical investigation118: 1944-54

171. Li Q, Zhang N, Zhang D, Wang Y, Lin T, Zhou H, Ye Z, Zhang F, Lin SC, Han J. 2008. Determinants that control the distinct subcellular localization of p38alpha-PRAK and p38beta-PRAK complexes. The Journal of biological chemistry 283: 11014-23

170. Kang YJ, Chen J, Otsuka M, Mols J, Ren S, Wang Y, Han J. 2008. Macrophage deletion of p38alpha partially impairs lipopolysaccharide-induced cellular activation. Journal of immunology180: 5075-82

169. Abidi P, Leers-Sucheta S, Cortez Y, Han J, Azhar S. 2008. Evidence that age-related changes in p38 MAP kinase contribute to the decreased steroid production by the adrenocortical cells from old rats. Aging cell7: 168-78

168. Xu C, Gu Y, Hou W, Cheng T, Zhang T, Que Y, Gao S, Zhang J, Han J, Xia N. 2008. [Construction of a novel gene therapy lentiviral vector for drug resistant selection and detection in vivo]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology 24: 256-61

167. Yang Z, Cheng W, Hong L, Chen W, Wang Y, Lin S, Han J, Zhou H, Gu J. 2007. Adenine nucleotide (ADP/ATP) translocase 3 participates in the tumor necrosis factor induced apoptosis of MCF-7 cells. Molecular biology of the cell18: 4681-9

166. Kang YJ, Kusler B, Otsuka M, Hughes M, Suzuki N, Suzuki S, Yeh WC, Akira S, Han J, Jones PP. 2007. Calcineurin negatively regulates TLR-mediated activation pathways. Journal of immunology179: 4598-607

165. Gills JJ, Castillo SS, Zhang C, Petukhov PA, Memmott RM, Hollingshead M, Warfel N, Han J, Kozikowski AP, Dennis PA. 2007. Phosphatidylinositol ether lipid analogues that inhibit AKT also independently activate the stress kinase, p38alpha, through MKK3/6-independent and -dependent mechanisms. The Journal of biological chemistry 282: 27020-9

164. Ha SD, Ng D, Lamothe J, Valvano MA, Han J, Kim SO. 2007. Mitochondrial proteins Bnip3 and Bnip3L are involved in anthrax lethal toxin-induced macrophage cell death. The Journal of biological chemistry 282: 26275-83

163. Hisatsune J, Yamasaki E, Nakayama M, Shirasaka D, Kurazono H, Katagata Y, Inoue H, Han J, Sap J, Yahiro K, Moss J, Hirayama T. 2007. Helicobacter pylori VacA enhances prostaglandin E2 production through induction of cyclooxygenase 2 expression via a p38 mitogen-activated protein kinase/activating transcription factor 2 cascade in AZ-521 cells. Infection and immunity75: 4472-81

162. Rui Y, Xu Z, Xiong B, Cao Y, Lin S, Zhang M, Chan SC, Luo W, Han Y, Lu Z, Ye Z, Zhou HM, Han J, Meng A, Lin SC. 2007. A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida. Developmental cell13: 268-82

161. Cook R, Wu CC, Kang YJ, Han J. 2007. The role of the p38 pathway in adaptive immunity. Cellular & molecular immunology 4: 253-9

160. Han J, Sun P. 2007. The pathways to tumor suppression via route p38. Trends in biochemical sciences32: 364-71

159. Otsuka M, Jing Q, Georgel P, New L, Chen J, Mols J, Kang YJ, Jiang Z, Du X, Cook R, Das SC, Pattnaik AK, Beutler B, Han J. 2007. Hypersusceptibility to vesicular stomatitis virus infection in Dicer1-deficient mice is due to impaired miR24 and miR93 expression.Immunity27: 123-34

158. Hao F, Tan M, Xu X, Han J, Miller DD, Tigyi G, Cui MZ. 2007. Lysophosphatidic acid induces prostate cancer PC3 cell migration via activation of LPA(1), p42 and p38alpha. Biochimica et biophysica acta1771: 883-92

157. Lu M, Lin SC, Huang Y, Kang YJ, Rich R, Lo YC, Myszka D, Han J, Wu H. 2007. XIAP induces NF-kappaB activation via the BIR1/TAB1 interaction and BIR1 dimerization. Molecular cell26: 689-702

156. Kang YJ, Kim SO, Shimada S, Otsuka M, Seit-Nebi A, Kwon BS, Watts TH, Han J. 2007. Cell surface 4-1BBL mediates sequential signaling pathways 'downstream' of TLR and is required for sustained TNF production in macrophages. Nature immunology8: 601-9

155. Kim SO, Ha SD, Lee S, Stanton S, Beutler B, Han J. 2007. Mutagenesis by retroviral insertion in chemical mutagen-generated quasi-haploid mammalian cells. BioTechniques42: 493-501

154. Sun P, Yoshizuka N, New L, Moser BA, Li Y, Liao R, Xie C, Chen J, Deng Q, Yamout M, Dong MQ, Frangou CG, Yates JR, 3rd, Wright PE, Han J. 2007. PRAK is essential for ras-induced senescence and tumor suppression. Cell128: 295-308

153. Zou H, Li Q, Lin SC, Wu Z, Han J, Ye Z. 2007. Differential requirement of MKK4 and MKK7 in JNK activation by distinct scaffold proteins. FEBS letters581: 196-202

152. Zhuang S, Yan Y, Daubert RA, Han J, Schnellmann RG. 2007. ERK promotes hydrogen peroxide-induced apoptosis through caspase-3 activation and inhibition of Akt in renal epithelial cells. American journal of physiology. Renal physiology292: F440-7

151. Kang YJ, Seit-Nebi A, Davis RJ, Han J. 2006. Multiple activation mechanisms of p38alpha mitogen-activated protein kinase. The Journal of biological chemistry 281: 26225-34

150. Keum YS, Yu S, Chang PP, Yuan X, Kim JH, Xu C, Han J, Agarwal A, Kong AN. 2006. Mechanism of action of sulforaphane: inhibition of p38 mitogen-activated protein kinase isoforms contributing to the induction of antioxidant response element-mediated heme oxygenase-1 in human hepatoma HepG2 cells. Cancer research 66: 8804-13

149. Xu Y, Kim SO, Li Y, Han J. 2006. Autophagy contributes to caspase-independent macrophage cell death. The Journal of biological chemistry 281: 19179-87

148. Zohn IE, Li Y, Skolnik EY, Anderson KV, Han J, Niswander L. 2006. p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation. Cell125: 957-69

147. Zhou H, Zheng M, Chen J, Xie C, Kolatkar AR, Zarubin T, Ye Z, Akella R, Lin S, Goldsmith EJ, Han J. 2006. Determinants that control the specific interactions between TAB1 and p38alpha. Molecular and cellular biology26: 3824-34

146. Han J. 2006. MyD88 beyond Toll. Nature immunology7: 370-1

145. Liu W, Rui H, Wang J, Lin S, He Y, Chen M, Li Q, Ye Z, Zhang S, Chan SC, Chen YG, Han J, Lin SC. 2006. Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia. The EMBO journal25: 1646-58

144. Xu Y, Huang S, Liu ZG, Han J. 2006. Poly(ADP-ribose) polymerase-1 signaling to mitochondria in necrotic cell death requires RIP1/TRAF2-mediated JNK1 activation. The Journal of biological chemistry 281: 8788-95

143. Lu G, Kang YJ, Han J, Herschman HR, Stefani E, Wang Y. 2006. TAB-1 modulates intracellular localization of p38 MAP kinase and downstream signaling. The Journal of biological chemistry 281: 6087-95

142. da Silva Correia J, Miranda Y, Austin-Brown N, Hsu J, Mathison J, Xiang R, Zhou H, Li Q, Han J, Ulevitch RJ. 2006. Nod1-dependent control of tumor growth. Proceedings of the National Academy of Sciences of the United States of America 103: 1840-5

141. Li Z, Zhang G, Feil R, Han J, Du X. 2006. Sequential activation of p38 and ERK pathways by cGMP-dependent protein kinase leading to activation of the platelet integrin alphaIIb beta3. Blood107: 965-72

140. Fu J, Yang Z, Wei J, Han J, Gu J. 2006. Nuclear protein NP60 regulates p38 MAPK activity. Journal of cell science119: 115-23

139. Han J, Ulevitch RJ. 2005. Limiting inflammatory responses during activation of innate immunity. Nature immunology6: 1198-205

138. Zhou H, Zarubin T, Ji Z, Min Z, Zhu W, Downey JS, Lin S, Han J. 2005. Frequency and distribution of AP-1 sites in the human genome.DNA research : an international journal for rapid publication of reports on genes and genomes12: 139-50

137. Al Sarraj J, Vinson C, Han J, Thiel G. 2005. Regulation of GTP cyclohydrolase I gene transcription by basic region leucine zipper transcription factors. Journal of cellular biochemistry96: 1003-20

136. Shi GX, Han J, Andres DA. 2005. Rin GTPase couples nerve growth factor signaling to p38 and b-Raf/ERK pathways to promote neuronal differentiation. The Journal of biological chemistry 280: 37599-609

135. Meng F, Yamagiwa Y, Taffetani S, Han J, Patel T. 2005. IL-6 activates serum and glucocorticoid kinase via p38alpha mitogen-activated protein kinase pathway. American journal of physiology. Cell physiology289: C971-81

134. Xie C, Zhang N, Zhou H, Li J, Li Q, Zarubin T, Lin SC, Han J. 2005. Distinct roles of basal steady-state and induced H-ferritin in tumor necrosis factor-induced death in L929 cells. Molecular and cellular biology25: 6673-81

133. Tang J, Qi X, Mercola D, Han J, Chen G. 2005. Essential role of p38gamma in K-Ras transformation independent of phosphorylation.The Journal of biological chemistry 280: 23910-7

132. Zhu X, Mei M, Lee HG, Wang Y, Han J, Perry G, Smith MA. 2005. P38 activation mediates amyloid-beta cytotoxicity. Neurochemical research30: 791-6

131. Zarubin T, Jing Q, New L, Han J. 2005. Identification of eight genes that are potentially involved in tamoxifen sensitivity in breast cancer cells. Cell research 15: 439-46

130. Zhuang S, Yan Y, Han J, Schnellmann RG. 2005. p38 kinase-mediated transactivation of the epidermal growth factor receptor is required for dedifferentiation of renal epithelial cells after oxidant injury. The Journal of biological chemistry 280: 21036-42

129. Jing Q, Huang S, Guth S, Zarubin T, Motoyama A, Chen J, Di Padova F, Lin SC, Gram H, Han J. 2005. Involvement of microRNA in AU-rich element-mediated mRNA instability. Cell120: 623-34

128. Zarubin T, Han J. 2005. Activation and signaling of the p38 MAP kinase pathway. Cell research 15: 11-8

127. Rui Y, Xu Z, Lin S, Li Q, Rui H, Luo W, Zhou HM, Cheung PY, Wu Z, Ye Z, Li P, Han J, Lin SC. 2004. Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation. The EMBO journal23: 4583-94

126. Li J, Li Q, Xie C, Zhou H, Wang Y, Zhang N, Shao H, Chan SC, Peng X, Lin SC, Han J. 2004. Beta-actin is required for mitochondria clustering and ROS generation in TNF-induced, caspase-independent cell death. Journal of cell science117: 4673-80

125. Cao J, Semenova MM, Solovyan VT, Han J, Coffey ET, Courtney MJ. 2004. Distinct requirements for p38alpha and c-Jun N-terminal kinase stress-activated protein kinases in different forms of apoptotic neuronal death. The Journal of biological chemistry 279: 35903-13

124. Shen G, Hebbar V, Nair S, Xu C, Li W, Lin W, Keum YS, Han J, Gallo MA, Kong AN. 2004. Regulation of Nrf2 transactivation domain activity. The differential effects of mitogen-activated protein kinase cascades and synergistic stimulatory effect of Raf and CREB-binding protein. The Journal of biological chemistry 279: 23052-60

123. Qi X, Tang J, Pramanik R, Schultz RM, Shirasawa S, Sasazuki T, Han J, Chen G. 2004. p38 MAPK activation selectively induces cell death in K-ras-mutated human colon cancer cells through regulation of vitamin D receptor. The Journal of biological chemistry 279: 22138-44

122. Sakai A, Han J, Cato AC, Akira S, Li JD. 2004. Glucocorticoids synergize with IL-1beta to induce TLR2 expression via MAP Kinase Phosphatase-1-dependent dual Inhibition of MAPK JNK and p38 in epithelial cells. BMC molecular biology5: 2

121. Watanabe T, Jono H, Han J, Lim DJ, Li JD. 2004. Synergistic activation of NF-kappaB by nontypeable Haemophilus influenzae and tumor necrosis factor alpha. Proceedings of the National Academy of Sciences of the United States of America 101: 3563-8

120. Qi X, Borowicz S, Pramanik R, Schultz RM, Han J, Chen G. 2004. Estrogen receptor inhibits c-Jun-dependent stress-induced cell death by binding and modifying c-Jun activity in human breast cancer cells. The Journal of biological chemistry 279: 6769-77

119. Bossy-Wetzel E, Talantova MV, Lee WD, Scholzke MN, Harrop A, Mathews E, Gotz T, Han J, Ellisman MH, Perkins GA, Lipton SA. 2004. Crosstalk between nitric oxide and zinc pathways to neuronal cell death involving mitochondrial dysfunction and p38-activated K+ channels. Neuron41: 351-65

118. Bradley K, Scatizzi JC, Fiore S, Shamiyeh E, Koch AE, Firestein GS, Gorges LL, Kuntsman K, Pope RM, Moore TL, Han J, Perlman H. 2004. Retinoblastoma suppression of matrix metalloproteinase 1, but not interleukin-6, through a p38-dependent pathway in rheumatoid arthritis synovial fibroblasts. Arthritis and rheumatism50: 78-87

117. Hoebe K, Janssen EM, Kim SO, Alexopoulou L, Flavell RA, Han J, Beutler B. 2003. Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways. Nature immunology4: 1223-9

116. Pace BS, Qian XH, Sangerman J, Ofori-Acquah SF, Baliga BS, Han J, Critz SD. 2003. p38 MAP kinase activation mediates gamma-globin gene induction in erythroid progenitors. Experimental hematology31: 1089-96

115. Luo W, Ng WW, Jin LH, Ye Z, Han J, Lin SC. 2003. Axin utilizes distinct regions for competitive MEKK1 and MEKK4 binding and JNK activation. The Journal of biological chemistry 278: 37451-8

114. Shalizi A, Lehtinen M, Gaudilliere B, Donovan N, Han J, Konishi Y, Bonni A. 2003. Characterization of a neurotrophin signaling mechanism that mediates neuron survival in a temporally specific pattern.The Journal of neuroscience : the official journal of the Society for Neuroscience23: 7326-36

113. Li SP, Junttila MR, Han J, Kahari VM, Westermarck J. 2003. p38 Mitogen-activated protein kinase pathway suppresses cell survival by inducing dephosphorylation of mitogen-activated protein/extracellular signal-regulated kinase kinase1,2. Cancer research 63: 3473-7

112. New L, Jiang Y, Han J. 2003. Regulation of PRAK subcellular location by p38 MAP kinases. Molecular biology of the cell14: 2603-16

111. Kim SO, Ono K, Tobias PS, Han J. 2003. Orphan nuclear receptor Nur77 is involved in caspase-independent macrophage cell death.The Journal of experimental medicine197: 1441-52

110. Zhu WH, Han J, Nicosia RF. 2003. Requisite role of p38 MAPK in mural cell recruitment during angiogenesis in the rat aorta model.Journal of vascular research40: 140-8

109. Kim SO, Jing Q, Hoebe K, Beutler B, Duesbery NS, Han J. 2003. Sensitizing anthrax lethal toxin-resistant macrophages to lethal toxin-induced killing by tumor necrosis factor-alpha. The Journal of biological chemistry 278: 7413-21

108. Pramanik R, Qi X, Borowicz S, Choubey D, Schultz RM, Han J, Chen G. 2003. p38 isoforms have opposite effects on AP-1-dependent transcription through regulation of c-Jun. The determinant roles of the isoforms in the p38 MAPK signal specificity. The Journal of biological chemistry 278: 4831-9

107. Iwasa H, Han J, Ishikawa F. 2003. Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway. Genes to cells : devoted to molecular & cellular mechanisms8: 131-44

106. Yang K, Jiang Y, Han J, Gu J. 2003. The binding of actin to p38 MAPK and inhibiting its kinase activity in vitro. Science in China. Series C, Life sciences / Chinese Academy of Sciences46: 87-94

105. Hsu SC, Wu CC, Han J, Lai MZ. 2003. Involvement of p38 mitogen-activated protein kinase in different stages of thymocyte development. Blood101: 970-6

104. Ono K, Kim SO, Han J. 2003. Susceptibility of lysosomes to rupture is a determinant for plasma membrane disruption in tumor necrosis factor alpha-induced cell death. Molecular and cellular biology23: 665-76

103. Yong Q, Jiang Y, Han J, Gu J. 2002. Interaction of p38 MAP kinase with actin inhibits p38 activity in vitro. Science in China32: 347-54

102. Ge B, Xiong X, Jing Q, Mosley JL, Filose A, Bian D, Huang S, Han J. 2003. TAB1beta (transforming growth factor-beta-activated protein kinase 1-binding protein 1beta ), a novel splicing variant of TAB1 that interacts with p38alpha but not TAK1. The Journal of biological chemistry 278: 2286-93

101. Han Q, Leng J, Bian D, Mahanivong C, Carpenter KA, Pan ZK, Han J, Huang S. 2002. Rac1-MKK3-p38-MAPKAPK2 pathway promotes urokinase plasminogen activator mRNA stability in invasive breast cancer cells. The Journal of biological chemistry 277: 48379-85

100. Vachon PH, Harnois C, Grenier A, Dufour G, Bouchard V, Han J, Landry J, Beaulieu JF, Vezina A, Dydensborg AB, Gauthier R, Cote A, Drolet JF, Lareau F. 2002. Differentiation state-selective roles of p38 isoforms in human intestinal epithelial cell anoikis.Gastroenterology123: 1980-91

99. Imasato A, Desbois-Mouthon C, Han J, Kai H, Cato AC, Akira S, Li JD. 2002. Inhibition of p38 MAPK by glucocorticoids via induction of MAPK phosphatase-1 enhances nontypeable Haemophilus influenzae-induced expression of toll-like receptor 2. The Journal of biological chemistry 277: 47444-50

98. Leivonen SK, Chantry A, Hakkinen L, Han J, Kahari VM. 2002. Smad3 mediates transforming growth factor-beta-induced collagenase-3 (matrix metalloproteinase-13) expression in human gingival fibroblasts. Evidence for cross-talk between Smad3 and p38 signaling pathways.The Journal of biological chemistry 277: 46338-46

97. Reunanen N, Li SP, Ahonen M, Foschi M, Han J, Kahari VM. 2002. Activation of p38 alpha MAPK enhances collagenase-1 (matrix metalloproteinase (MMP)-1) and stromelysin-1 (MMP-3) expression by mRNA stabilization. The Journal of biological chemistry 277: 32360-8

96. Hoebe K, Du X, Georgel P, Janssen E, Tabeta K, Kim SO, Goode J, Lin P, Mann N, Mudd S, Crozat K, Sovath S, Han J, Beutler B. 2003. Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature424: 743-8

95. Qi X, Pramanik R, Wang J, Schultz RM, Maitra RK, Han J, DeLuca HF, Chen G. 2002. The p38 and JNK pathways cooperate to trans-activate vitamin D receptor via c-Jun/AP-1 and sensitize human breast cancer cells to vitamin D(3)-induced growth inhibition. The Journal of biological chemistry 277: 25884-92

94. Zhao M, Liu Y, Wang X, New L, Han J, Brunk UT. 2002. Activation of the p38 MAP kinase pathway is required for foam cell formation from macrophages exposed to oxidized LDL. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica110: 458-68

93. Zhang Y, Qiu WJ, Chan SC, Han J, He X, Lin SC. 2002. Casein kinase I and casein kinase II differentially regulate axin function in Wnt and JNK pathways. The Journal of biological chemistry 277: 17706-12

92. Shuto T, Imasato A, Jono H, Sakai A, Xu H, Watanabe T, Rixter DD, Kai H, Andalibi A, Linthicum F, Guan YL, Han J, Cato AC, Lim DJ, Akira S, Li JD. 2002. Glucocorticoids synergistically enhance nontypeable Haemophilus influenzae-induced Toll-like receptor 2 expression via a negative cross-talk with p38 MAP kinase. The Journal of biological chemistry 277: 17263-70

91. Zhao M, Liu Y, Bao M, Kato Y, Han J, Eaton JW. 2002. Vascular smooth muscle cell proliferation requires both p38 and BMK1 MAP kinases. Archives of biochemistry and biophysics400: 199-207

90. Mansky KC, Sankar U, Han J, Ostrowski MC. 2002. Microphthalmia transcription factor is a target of the p38 MAPK pathway in response to receptor activator of NF-kappa B ligand signaling. The Journal of biological chemistry 277: 11077-83

89. Ge B, Gram H, Di Padova F, Huang B, New L, Ulevitch RJ, Luo Y, Han J. 2002. MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha. Science295: 1291-4

88. Wang B, Lim DJ, Han J, Kim YS, Basbaum CB, Li JD. 2002. Novel cytoplasmic proteins of nontypeable Haemophilus influenzae up-regulate human MUC5AC mucin transcription via a positive p38 mitogen-activated protein kinase pathway and a negative phosphoinositide 3-kinase-Akt pathway. The Journal of biological chemistry 277: 949-57

87. Li W, Nadelman C, Henry G, Fan J, Muellenhoff M, Medina E, Gratch NS, Chen M, Han J, Woodley D. 2001. The p38-MAPK/SAPK pathway is required for human keratinocyte migration on dermal collagen. The Journal of investigative dermatology117: 1601-11

86. Ono K, Wang X, Han J. 2001. Resistance to tumor necrosis factor-induced cell death mediated by PMCA4 deficiency. Molecular and cellular biology21: 8276-88

85. New L, Li Y, Ge B, Zhong H, Mansbridge J, Liu K, Han J. 2001. SB203580 promotes EGF-stimulated early morphological differentiation in PC12 cell through activating ERK pathway. Journal of cellular biochemistry83: 585-96

84. Xi X, Han J, Zhang JZ. 2001. Stimulation of glucose transport by AMP-activated protein kinase via activation of p38 mitogen-activated protein kinase. The Journal of biological chemistry 276: 41029-34

83. Feranchak AP, Berl T, Capasso J, Wojtaszek PA, Han J, Fitz JG. 2001. p38 MAP kinase modulates liver cell volume through inhibition of membrane Na+ permeability. The Journal of clinical investigation108: 1495-504

82. Kim SO, Ono K, Han J. 2001. Apoptosis by pan-caspase inhibitors in lipopolysaccharide-activated macrophages. American journal of physiology. Lung cellular and molecular physiology281: L1095-105

81. Liu ZG, Han J. 2001. Cellular responses to tumor necrosis factor. Current issues in molecular biology3: 79-90

80. Sun J, Li M, Han J, Gu J. 2001. Sensitization of differentiated PC12 cells to apoptosis by presenilin-2 is mediated by p38. Biochemical and biophysical research communications287: 536-41

79. Zhu W, Brauchle MA, Di Padova F, Gram H, New L, Ono K, Downey JS, Han J. 2001. Gene suppression by tristetraprolin and release by the p38 pathway. American journal of physiology. Lung cellular and molecular physiology281: L499-508

78. Guo YL, Kang B, Han J, Williamson JR. 2001. p38beta MAP kinase protects rat mesangial cells from TNF-alpha-induced apoptosis.Journal of cellular biochemistry82: 556-65

77. Kim SO, Han J. 2001. Pan-caspase inhibitor zVAD enhances cell death in RAW246.7 macrophages. Journal of Endotoxin Research7: 292-6

76. Shuto T, Xu H, Wang B, Han J, Kai H, Gu XX, Murphy TF, Lim DJ, Li JD. 2001. Activation of NF-kappa B by nontypeable Hemophilus influenzae is mediated by toll-like receptor 2-TAK1-dependent NIK-IKK alpha /beta-I kappa B alpha and MKK3/6-p38 MAP kinase signaling pathways in epithelial cells. Proceedings of the National Academy of Sciences of the United States of America 98: 8774-9

75. Foschi M, Franchi F, Han J, La Villa G, Sorokin A. 2001. Endothelin-1 induces serine phosphorylation of the adaptor protein p66Shc and its association with 14-3-3 protein in glomerular mesangial cells. The Journal of biological chemistry 276: 26640-7

74. Wang X, Ono K, Kim SO, Kravchenko V, Lin SC, Han J. 2001. Metaxin is required for tumor necrosis factor-induced cell death. EMBO reports2: 628-33

73. Lim HW, New L, Han J, Molkentin JD. 2001. Calcineurin enhances MAPK phosphatase-1 expression and p38 MAPK inactivation in cardiac myocytes. The Journal of biological chemistry 276: 15913-9

72. Westermarck J, Li SP, Kallunki T, Han J, Kahari VM. 2001. p38 mitogen-activated protein kinase-dependent activation of protein phosphatases 1 and 2A inhibits MEK1 and MEK2 activity and collagenase 1 (MMP-1) gene expression. Molecular and cellular biology21: 2373-83

71. Ravanti L, Toriseva M, Penttinen R, Crombleholme T, Foschi M, Han J, Kahari VM. 2001. Expression of human collagenase-3 (MMP-13) by fetal skin fibroblasts is induced by transforming growth factor beta via p38 mitogen-activated protein kinase. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology15: 1098-100

70. Gong X, Wang X, Han J, Niesman I, Huang Q, Horwitz J. 2001. Development of cataractous macrophthalmia in mice expressing an active MEK1 in the lens. Investigative ophthalmology & visual science42: 539-48

69. Li Y, Jiang B, Ensign WY, Vogt PK, Han J. 2000. Myogenic differentiation requires signalling through both phosphatidylinositol 3-kinase and p38 MAP kinase. Cellular signalling12: 751-7

68. Chen G, Hitomi M, Han J, Stacey DW. 2000. The p38 pathway provides negative feedback for Ras proliferative signaling. The Journal of biological chemistry 275: 38973-80

67. McGinty A, Foschi M, Chang YW, Han J, Dunn MJ, Sorokin A. 2000. Induction of prostaglandin endoperoxide synthase 2 by mitogen-activated protein kinase cascades. The Biochemical journal352 Pt 2: 419-24

66. Reunanen N, Foschi M, Han J, Kahari VM. 2000. Activation of extracellular signal-regulated kinase 1/2 inhibits type I collagen expression by human skin fibroblasts. The Journal of biological chemistry 275: 34634-9

65. Li RC, Ping P, Zhang J, Wead WB, Cao X, Gao J, Zheng Y, Huang S, Han J, Bolli R. 2000. PKCepsilon modulates NF-kappaB and AP-1 via mitogen-activated protein kinases in adult rabbit cardiomyocytes. American journal of physiology. Heart and circulatory physiology279: H1679-89

64. Zhang Y, Neo SY, Han J, Lin SC. 2000. Dimerization choices control the ability of axin and dishevelled to activate c-Jun N-terminal kinase/stress-activated protein kinase. The Journal of biological chemistry 275: 25008-14

63. Wang X, McGowan CH, Zhao M, He L, Downey JS, Fearns C, Wang Y, Huang S, Han J. 2000. Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest. Molecular and cellular biology20: 4543-52

62. Brauchle M, Gluck D, Di Padova F, Han J, Gram H. 2000. Independent role of p38 and ERK1/2 mitogen-activated kinases in the upregulation of matrix metalloproteinase-1. Experimental cell research 258: 135-44

61. Zhu W, Downey JS, Gu J, Di Padova F, Gram H, Han J. 2000. Regulation of TNF expression by multiple mitogen-activated protein kinase pathways. Journal of immunology164: 6349-58

60. Wang X, Han J. 2000. Elucidating tumor necrosis factor signaling pathway using a functional gene identification approach. Immunologic research21: 55-61

59. Fearns C, Kline L, Gram H, Di Padova F, Zurini M, Han J, Ulevitch RJ. 2000. Coordinate activation of endogenous p38alpha, beta, gamma, and delta by inflammatory stimuli. Journal of leukocyte biology67: 705-11

58. Huang S, New L, Pan Z, Han J, Nemerow GR. 2000. Urokinase plasminogen activator/urokinase-specific surface receptor expression and matrix invasion by breast cancer cells requires constitutive p38alpha mitogen-activated protein kinase activity. The Journal of biological chemistry 275: 12266-72

57. Tschopp C, Knauf U, Brauchle M, Zurini M, Ramage P, Glueck D, New L, Han J, Gram H. 2000. Phosphorylation of eIF-4E on Ser 209 in response to mitogenic and inflammatory stimuli is faithfully detected by specific antibodies. Molecular cell biology research communications : MCBRC3: 205-11

56. Puri PL, Wu Z, Zhang P, Wood LD, Bhakta KS, Han J, Feramisco JR, Karin M, Wang JY. 2000. Induction of terminal differentiation by constitutive activation of p38 MAP kinase in human rhabdomyosarcoma cells.Genes & development14: 574-84

55. Ono K, Han J. 2000. The p38 signal transduction pathway: activation and function. Cellular signalling12: 1-13

54. Han J, Molkentin JD. 2000. Regulation of MEF2 by p38 MAPK and its implication in cardiomyocyte biology. Trends in cardiovascular medicine10: 19-22

53. Ravanti L, Hakkinen L, Larjava H, Saarialho-Kere U, Foschi M, Han J, Kahari VM. 1999. Transforming growth factor-beta induces collagenase-3 expression by human gingival fibroblasts via p38 mitogen-activated protein kinase. The Journal of biological chemistry 274: 37292-300

52. Zhang Y, Neo SY, Wang X, Han J, Lin SC. 1999. Axin forms a complex with MEKK1 and activates c-Jun NH(2)-terminal kinase/stress-activated protein kinase through domains distinct from Wnt signaling. The Journal of biological chemistry 274: 35247-54

51. Ping P, Zhang J, Huang S, Cao X, Tang XL, Li RC, Zheng YT, Qiu Y, Clerk A, Sugden P, Han J, Bolli R. 1999. PKC-dependent activation of p46/p54 JNKs during ischemic preconditioning in conscious rabbits. The American journal of physiology277: H1771-85

50. Wang AH, Bertos NR, Vezmar M, Pelletier N, Crosato M, Heng HH, Th'ng J, Han J, Yang XJ. 1999. HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor. Molecular and cellular biology19: 7816-27

49. Hsu SC, Gavrilin MA, Tsai MH, Han J, Lai MZ. 1999. p38 mitogen-activated protein kinase is involved in Fas ligand expression. The Journal of biological chemistry 274: 25769-76

48. Conrad PW, Rust RT, Han J, Millhorn DE, Beitner-Johnson D. 1999. Selective activation of p38alpha and p38gamma by hypoxia. Role in regulation of cyclin D1 by hypoxia in PC12 cells. The Journal of biological chemistry 274: 23570-6

47. Alpert D, Schwenger P, Han J, Vilcek J. 1999. Cell stress and MKK6b-mediated p38 MAP kinase activation inhibit tumor necrosis factor-induced IkappaB phosphorylation and NF-kappaB activation. The Journal of biological chemistry 274: 22176-83

46. Zhu W, Downey JS, Li YQ, Han J. 1999. Co-ordinated regulation of TNF expression by multiple MAP kinase pathways. Journal of Endotoxin Research5: 239-43

45. Han J, Ulevitch RJ. 1999. Emerging targets for anti-inflammatory therapy. Nature cell biology 1: E39-40

44. Zhang Y, Neo SY, Han J, Yaw LP, Lin SC. 1999. RGS16 attenuates galphaq-dependent p38 mitogen-activated protein kinase activation by platelet-activating factor. The Journal of biological chemistry 274: 2851-7

43. Zhao M, New L, Kravchenko VV, Kato Y, Gram H, di Padova F, Olson EN, Ulevitch RJ, Han J. 1999. Regulation of the MEF2 family of transcription factors by p38. Molecular and cellular biology19: 21-30

42. New L, Zhao M, Li Y, Bassett WW, Feng Y, Ludwig S, Padova FD, Gram H, Han J. 1999. Cloning and characterization of RLPK, a novel RSK-related protein kinase. The Journal of biological chemistry 274: 1026-32

41. Kusuhara M, Takahashi E, Peterson TE, Abe J, Ishida M, Han J, Ulevitch R, Berk BC. 1998. p38 Kinase is a negative regulator of angiotensin II signal transduction in vascular smooth muscle cells: effects on Na+/H+ exchange and ERK1/2. Circulation research83: 824-31

40. New L, Han J. 1998. The p38 MAP kinase pathway and its biological function. Trends in cardiovascular medicine8: 220-8

39. New L, Jiang Y, Zhao M, Liu K, Zhu W, Flood LJ, Kato Y, Parry GC, Han J. 1998. PRAK, a novel protein kinase regulated by the p38 MAP kinase. The EMBO journal17: 3372-84

38. Yang J, New L, Jiang Y, Han J, Su B. 1998. Molecular cloning and characterization of a human protein kinase that specifically activates c-Jun N-terminal kinase. Gene212: 95-102

37. Han J, Bohuslav J, Jiang Y, Kravchenko VV, Lee JD, Li ZJ, Mathison J, Richter B, Tobias P, Ulevitch RJ. 1998. CD14 dependent mechanisms of cell activation. Progress in clinical and biological research397: 157-68

36. Downey JS, Han J. 1998. Cellular activation mechanisms in septic shock. Frontiers in bioscience : a journal and virtual library3: d468-76

35. Wang Y, Su B, Sah VP, Brown JH, Han J, Chien KR. 1998. Cardiac hypertrophy induced by mitogen-activated protein kinase kinase 7, a specific activator for c-Jun NH2-terminal kinase in ventricular muscle cells. The Journal of biological chemistry 273: 5423-6

34. Ludwig S, Hoffmeyer A, Goebeler M, Kilian K, Hafner H, Neufeld B, Han J, Rapp UR. 1998. The stress inducer arsenite activates mitogen-activated protein kinases extracellular signal-regulated kinases 1 and 2 via a MAPK kinase 6/p38-dependent pathway. The Journal of biological chemistry 273: 1917-22

33. Wang Y, Huang S, Sah VP, Ross J, Jr., Brown JH, Han J, Chien KR. 1998. Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family. The Journal of biological chemistry 273: 2161-8

32. Kato Y, Kravchenko VV, Tapping RI, Han J, Ulevitch RJ, Lee JD. 1997. BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C. The EMBO journal16: 7054-66

31. Jiang Y, Gram H, Zhao M, New L, Gu J, Feng L, Di Padova F, Ulevitch RJ, Han J. 1997. Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38delta. The Journal of biological chemistry 272: 30122-8

30. Huang S, Jiang Y, Li Z, Nishida E, Mathias P, Lin S, Ulevitch RJ, Nemerow GR, Han J. 1997. Apoptosis signaling pathway in T cells is composed of ICE/Ced-3 family proteases and MAP kinase kinase 6b. Immunity6: 739-49

29. Jiang Y, Li Z, Schwarz EM, Lin A, Guan K, Ulevitch RJ, Han J. 1997. Structure-function studies of p38 mitogen-activated protein kinase. Loop 12 influences substrate specificity and autophosphorylation, but not upstream kinase selection. The Journal of biological chemistry272: 11096-102

28. Chen C, Zheng B, Han J, Lin SC. 1997. Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast. The Journal of biological chemistry 272: 8679-85

27. Han J, Jiang Y, Li Z, Kravchenko VV, Ulevitch RJ. 1997. Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation. Nature386: 296-9

26. Wang Z, Harkins PC, Ulevitch RJ, Han J, Cobb MH, Goldsmith EJ. 1997. The structure of mitogen-activated protein kinase p38 at 2.1-A resolution. Proceedings of the National Academy of Sciences of the United States of America 94: 2327-32

25. Su YC, Han J, Xu S, Cobb M, Skolnik EY. 1997. NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain. The EMBO journal16: 1279-90

24. Han J, Wang X, Jiang Y, Ulevitch RJ, Lin S. 1997. Identification and characterization of a predominant isoform of human MKK3. FEBS letters403: 19-22

23. Li Z, Jiang Y, Ulevitch RJ, Han J. 1996. The primary structure of p38 gamma: a new member of p38 group of MAP kinases.Biochemical and biophysical research communications228: 334-40

22. El Benna J, Han J, Park JW, Schmid E, Ulevitch RJ, Babior BM. 1996. Activation of p38 in stimulated human neutrophils: phosphorylation of the oxidase component p47phox by p38 and ERK but not by JNK. Archives of biochemistry and biophysics334: 395-400

21. Jiang Y, Chen C, Li Z, Guo W, Gegner JA, Lin S, Han J. 1996. Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta). The Journal of biological chemistry 271: 17920-6

20. Han J, Lee JD, Jiang Y, Li Z, Feng L, Ulevitch RJ. 1996. Characterization of the structure and function of a novel MAP kinase kinase (MKK6). The Journal of biological chemistry 271: 2886-91

19. Zhang S, Han J, Sells MA, Chernoff J, Knaus UG, Ulevitch RJ, Bokoch GM. 1995. Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1. The Journal of biological chemistry 270: 23934-6

18. Shyy JY, Lin MC, Han J, Lu Y, Petrime M, Chien S. 1995. The cis-acting phorbol ester "12-O-tetradecanoylphorbol 13-acetate"-responsive element is involved in shear stress-induced monocyte chemotactic protein 1 gene expression. Proceedings of the National Academy of Sciences of the United States of America 92: 8069-73

17. Lee JD, Ulevitch RJ, Han J. 1995. Primary structure of BMK1: a new mammalian map kinase. Biochemical and biophysical research communications213: 715-24

16. Kravchenko VV, Pan Z, Han J, Herbert JM, Ulevitch RJ, Ye RD. 1995. Platelet-activating factor induces NF-kappa B activation through a G protein-coupled pathway. The Journal of biological chemistry 270: 14928-34

15. Raingeaud J, Gupta S, Rogers JS, Dickens M, Han J, Ulevitch RJ, Davis RJ. 1995. Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. The Journal of biological chemistry 270: 7420-6

14. Han J, Richter B, Li Z, Kravchenko V, Ulevitch RJ. 1995. Molecular cloning of human p38 MAP kinase. Biochimica et biophysica acta1265: 224-7

13. Derijard B, Raingeaud J, Barrett T, Wu IH, Han J, Ulevitch RJ, Davis RJ. 1995. Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms. Science267: 682-5

12. Han J, Lee JD, Bibbs L, Ulevitch RJ. 1994. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science265: 808-11

11. Han J, Mathison JC, Ulevitch RJ, Tobias PS. 1994. Lipopolysaccharide (LPS) binding protein, truncated at Ile-197, binds LPS but does not transfer LPS to CD14. The Journal of biological chemistry 269: 8172-5

10. Tobias PS, Gegner J, Han J, Kirkland T, Kravchenko V, Leturcq D, Lee JD, Moriarty A, Mathison JC, Pugin J, et al. 1994. LPS binding protein and CD14 in the LPS dependent activation of cells. Progress in clinical and biological research388: 31-9

9. Han J, Lee JD, Tobias PS, Ulevitch RJ. 1993. Endotoxin induces rapid protein tyrosine phosphorylation in 70Z/3 cells expressing CD14.The Journal of biological chemistry 268: 25009-14

8. Lee JD, Kravchenko V, Kirkland TN, Han J, Mackman N, Moriarty A, Leturcq D, Tobias PS, Ulevitch RJ. 1993. Glycosyl-phosphatidylinositol-anchored or integral membrane forms of CD14 mediate identical cellular responses to endotoxin. Proceedings of the National Academy of Sciences of the United States of America 90: 9930-4

7. Han J, Beutler B, Huez G. 1991. Complex regulation of tumor necrosis factor mRNA turnover in lipopolysaccharide-activated macrophages. Biochimica et biophysica acta1090: 22-8

6. Han J, Huez G, Beutler B. 1991. Interactive effects of the tumor necrosis factor promoter and 3'-untranslated regions. Journal of immunology146: 1843-8

5. Han J, Thompson P, Beutler B. 1990. Dexamethasone and pentoxifylline inhibit endotoxin-induced cachectin/tumor necrosis factor synthesis at separate points in the signaling pathway. The Journal of experimental medicine172: 391-4

4. Han J, Beutler B. 1990. The essential role of the UA-rich sequence in endotoxin-induced cachectin/TNF synthesis. European cytokine network1: 71-5

3. Han J, Brown T, Beutler B. 1990. Endotoxin-responsive sequences control cachectin/tumor necrosis factor biosynthesis at the translational level. The Journal of experimental medicine171: 465-75

2. Beutler E, Gelbart T, Han J, Koziol JA, Beutler B. 1989. Evolution of the genome and the genetic code: selection at the dinucleotide level by methylation and polyribonucleotide cleavage. Proceedings of the National Academy of Sciences of the United States of America 86: 192-6

1. Han J, Z. W, L. Z. 1986. Isolation and characterization of Bear C-reactive protein. Acta Scientiarum Universitatis Pekinenis4: 3




3. R.J. U, J.C. M, J-D. L,Han J, V. K, J. G, J. P, S. S, D. L, A. M, T. K, P.S. T. 1994. CD14 and lipopolysaccharide binding protein control host responses to bacterial lipopolysaccharide.. Molecular Pathogenesis of Periodontal Disease (R. Genco et al., eds.) 119-25

2. P.S. T, J. G, Han J, T. K, V. K, D. L, J.-D. L, A. M, J.C. M, J. P, S. S, R.J. U. 1993. LPS binding protein and CD14 in the LPS dependent activation of cells. In: Bacterial Endotoxins: Basic Science to Anti-Sepsis Strategies (J. Levin, S.J.H. van Deventer, T. van der Poll and A. Sturk (eds.) John Wiley & Sons, Inc.: 31-9

1. B. B, Han J, V. K. 1992. Coordinated regulation of TNF expression at translational and transcriptional level. In: Tumor Necrosis Factors (B. Beutler, ed.). Raven Press, New York

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